Fig. 7. Proposed model of HIF-1α degradation by SM compounds in hypoxia. SM compounds prevent HIF-1α:HSP90 binding which allows the PHDs to hydroxylate HIF-1α, even under low oxygen conditions, targeting HIF-1α for proteasomal degradation.
Fig. 7. Proposed model of HIF-1α degradation by SM compounds in hypoxia. SM compounds prevent HIF-1α:HSP90 binding which allows the PHDs to hydroxylate HIF-1α, even under low oxygen conditions, targeting HIF-1α for proteasomal degradation.